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Why Patients With Sleep Disorders Choose Modafinil

The drug is a wakefulness-promoting agent, and its precise mechanism of action in the brain is not fully understood. It is thought to inhibit the reuptake of dopamine and norepinephrine in the ventrolateral preoptic nucleus of the hypothalamus, which stimulates orexinergic neurons that cause wakefulness. It also increases orexinergic neuron activity in the suprachiasmatic nucleus, which is involved in regulation of sleep and wakefulness. It also has stimulant actions on the central nervous system, and it may increase blood pressure, although this effect is less pronounced than those seen with the drug’s close relative armodafinil (AWP-500).

In six placebo-controlled clinical studies of people with narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), or shift work sleep disorder (SWSD), once-daily modafinil was found to be safe and effective at increasing wakefulness. A primary end point of these studies was either a Multiple Sleep Latency Test (MSLT) or a Maintenance of Wakefulness Test (MWT). In five of the six studies, modafinil significantly improved subjective and objective measures of excessive sleepiness and wakefulness. The one exception was a study in which investigator-rated clinical improvement in investigators’ impression of the patient’s condition was used.

Buy Modafinil Online is also a safe and effective choice for patients with SWSD, especially those who have a difficult time falling or staying asleep during their scheduled sleeping hours because of their night or rotating shift schedule. In a double-blind, placebo-controlled study of patients with SWSD who worked night shifts and reported difficulty in maintaining wakefulness, modafinil was found to be more effective than placebo at improving objective and subjective measures of excessive sleepiness, including a night-time MSLT and a morning MWT.

Patients should not take modafinil for more than 12 weeks without consulting their doctor. It is important to continue to get enough sleep and follow their doctor’s advice about good sleep habits. In addition, it is vital to continue using breathing devices or other treatments prescribed for their underlying sleep disorder.

Warnings/Concerns Modafinil can impair thinking or reactions. Avoid driving or operating machinery until you know how the medication affects you. Tell your doctor if you have chest pain or discomfort, trouble breathing, or uncoordinated movements. Do not take this medicine if you have a history of heart disease, liver disease, or kidney disease; or if you have had a serious allergic reaction to it or any other medicines.

Take this medicine by mouth with or without food as directed by your doctor. Do not change the dose or stop taking it except on your doctor’s advice. Use caution when taking this medicine in the elderly; it may make them more sensitive to the effects of heat or light.

Keep out of the reach of children. Store at room temperature and away from excess heat or moisture. Keep track of how many tablets are left so you do not overdose.

This medication interacts with certain narcotic, barbiturate, and MAO inhibitors. It also interacts with alcohol and other sedating drugs. Therefore, you should not drink alcohol or take other sedating drugs while you are taking this medicine.